Lipid-induced insulin resistance: unravelling the mechanism
نویسندگان
چکیده
منابع مشابه
Lipid-induced hepatic insulin resistance
principal function of insulin in the liver is to suppress glucose production when blood glucose concentrations increase. This process is impaired in hepatic insulin resistance and contributes to postprandial hyperglycemia. The development of hepatic insulin resistance is very closely linked to non alcoholic fatty liver disease (NAFLD), and is a major factor in the pathogenesis of type 2 diabete...
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Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties....
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Lipid abnormalities such as obesity, increased circulating free fatty acid levels, and excess intramyocellular lipid accumulation are frequently associated with insulin resistance. These observations have prompted investigators to speculate that the accumulation of lipids in tissues not suited for fat storage (e.g., skeletal muscle and liver) is an underlying component of insulin resistance and...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2010
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(10)60408-4